Integration of Mendelian Randomization to explore the genetic influences of pediatric sepsis: a focus on RGL4, ATP9A, MAP3K7CL, and DDX11L2

Integration of Mendelian Randomization to explore the genetic influences of pediatric sepsis: a focus on RGL4, ATP9A, MAP3K7CL, and DDX11L2

Abstract Objective This study aims to explore the genetic characteristics of pediatric sepsis through a combined analysis of multiple methods, including Mendelian Randomization (MR), differential gene expression analysis, and immune cell infiltration assessment. It explores their potential as biomar...

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Bibliographic Details
Main Authors: Liuzhao Zhang, Quanwang Chu, Shuyue Jiang, Bo Shao
Format: Article
Language:English
Published: BMC 2025-01-01
Series:BMC Pediatrics
Subjects:
Pediatric sepsis
Mendelian Randomization
Differential expression analysis
RGL4
ATP9A
MAP3K7CL
Online Access:https://doi.org/10.1186/s12887-025-05424-y
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