Comparative study between corticosteroids and colchicine effect on interleukin-6 and Krebs-von-den Lungen-6 in treatment of post covid pulmonary fibrosis
Background Interstitial lung diseases (ILDs) involve a diverse range of over 200 lung disorders, constituting a vast group of diseases. This study aimed to compare Corticosteroids and Colchicine in the treatment of post-covid pulmonary fibrosis (PC19-PF) through the assessment of effects of these...
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2024-07-01
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| Series: | Egyptian Journal of Chest Disease and Tuberculosis |
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| Online Access: | https://journals.lww.com/ecdt/fulltext/2024/07000/comparative_study_between_corticosteroids_and.4.aspx |
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| author | Mohamed A. E. G. Bedir Fawzy A. E. Elemery Mohamed T. A. Elghafar Mohamed Torky |
| author_facet | Mohamed A. E. G. Bedir Fawzy A. E. Elemery Mohamed T. A. Elghafar Mohamed Torky |
| author_sort | Mohamed A. E. G. Bedir |
| collection | DOAJ |
| description | Background
Interstitial lung diseases (ILDs) involve a diverse range of over 200 lung disorders, constituting a vast group of diseases. This study aimed to compare Corticosteroids and Colchicine in the treatment of post-covid pulmonary fibrosis (PC19-PF) through the assessment of effects of these drugs on some biomarkers as interleukin-6 (IL6) and Krebs-von-den Lungen-6 (KL6).
Method
This randomized controlled study was carried out 30 patients with PC19-PF and 10 healthy volunteers. All patients were randomly classified into four equal groups: group 1: received corticosteroids in the dose of 0.5 mg/kg/day. Group 2: received colchicine in the dose of 500 µg/12 h for 1 month. Group 3: received both corticosteroids in the dose of 0.5 mg/kg/day and colchicine in the dose of 500µg/12 h for 1 month. Group 4: healthy volunteers.
Results
A 45 pg/ml was the cut off value used to demonstrate the effect of treatment on serum IL6 in studied PC19-PF patients, with a sensitivity of 77% and 70% specificity. 180 U/ml was the cut off value used to demonstrate the effect of treatment on serum KL6, serum KL6 levels provide sensitivity of 67% and 70% specificity for the effect of treatment on serum KL6. The decrease in serum IL6 and KL6 after treatment was in group 3, followed by group 1 then group 2.
Conclusion
Prednisolone and colchicine were better than prednisolone alone in treatment of PC19-PF and colchicine alone showed slight improvement. |
| format | Article |
| id | doaj-art-e4da7a089d02410e940b06b045d12e9c |
| institution | OA Journals |
| issn | 2090-9950 |
| language | English |
| publishDate | 2024-07-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Egyptian Journal of Chest Disease and Tuberculosis |
| spelling | doaj-art-e4da7a089d02410e940b06b045d12e9c2025-08-20T02:13:58ZengWolters Kluwer Medknow PublicationsEgyptian Journal of Chest Disease and Tuberculosis2090-99502024-07-0173322523210.4103/ecdt.ecdt_12_24Comparative study between corticosteroids and colchicine effect on interleukin-6 and Krebs-von-den Lungen-6 in treatment of post covid pulmonary fibrosisMohamed A. E. G. BedirFawzy A. E. ElemeryMohamed T. A. ElghafarMohamed TorkyBackground Interstitial lung diseases (ILDs) involve a diverse range of over 200 lung disorders, constituting a vast group of diseases. This study aimed to compare Corticosteroids and Colchicine in the treatment of post-covid pulmonary fibrosis (PC19-PF) through the assessment of effects of these drugs on some biomarkers as interleukin-6 (IL6) and Krebs-von-den Lungen-6 (KL6). Method This randomized controlled study was carried out 30 patients with PC19-PF and 10 healthy volunteers. All patients were randomly classified into four equal groups: group 1: received corticosteroids in the dose of 0.5 mg/kg/day. Group 2: received colchicine in the dose of 500 µg/12 h for 1 month. Group 3: received both corticosteroids in the dose of 0.5 mg/kg/day and colchicine in the dose of 500µg/12 h for 1 month. Group 4: healthy volunteers. Results A 45 pg/ml was the cut off value used to demonstrate the effect of treatment on serum IL6 in studied PC19-PF patients, with a sensitivity of 77% and 70% specificity. 180 U/ml was the cut off value used to demonstrate the effect of treatment on serum KL6, serum KL6 levels provide sensitivity of 67% and 70% specificity for the effect of treatment on serum KL6. The decrease in serum IL6 and KL6 after treatment was in group 3, followed by group 1 then group 2. Conclusion Prednisolone and colchicine were better than prednisolone alone in treatment of PC19-PF and colchicine alone showed slight improvement.https://journals.lww.com/ecdt/fulltext/2024/07000/comparative_study_between_corticosteroids_and.4.aspxcolchicine; corticosteroids; covid pulmonary fibrosis; interleukin-6; krebs-von-den lungen-6 |
| spellingShingle | Mohamed A. E. G. Bedir Fawzy A. E. Elemery Mohamed T. A. Elghafar Mohamed Torky Comparative study between corticosteroids and colchicine effect on interleukin-6 and Krebs-von-den Lungen-6 in treatment of post covid pulmonary fibrosis Egyptian Journal of Chest Disease and Tuberculosis colchicine; corticosteroids; covid pulmonary fibrosis; interleukin-6; krebs-von-den lungen-6 |
| title | Comparative study between corticosteroids and colchicine effect on interleukin-6 and Krebs-von-den Lungen-6 in treatment of post covid pulmonary fibrosis |
| title_full | Comparative study between corticosteroids and colchicine effect on interleukin-6 and Krebs-von-den Lungen-6 in treatment of post covid pulmonary fibrosis |
| title_fullStr | Comparative study between corticosteroids and colchicine effect on interleukin-6 and Krebs-von-den Lungen-6 in treatment of post covid pulmonary fibrosis |
| title_full_unstemmed | Comparative study between corticosteroids and colchicine effect on interleukin-6 and Krebs-von-den Lungen-6 in treatment of post covid pulmonary fibrosis |
| title_short | Comparative study between corticosteroids and colchicine effect on interleukin-6 and Krebs-von-den Lungen-6 in treatment of post covid pulmonary fibrosis |
| title_sort | comparative study between corticosteroids and colchicine effect on interleukin 6 and krebs von den lungen 6 in treatment of post covid pulmonary fibrosis |
| topic | colchicine; corticosteroids; covid pulmonary fibrosis; interleukin-6; krebs-von-den lungen-6 |
| url | https://journals.lww.com/ecdt/fulltext/2024/07000/comparative_study_between_corticosteroids_and.4.aspx |
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