Successful cardiac resynchronization therapy reduces negative septal work in patient-specific models of dyssynchronous heart failure.

Successful cardiac resynchronization therapy reduces negative septal work in patient-specific models of dyssynchronous heart failure.

In patients with dyssynchronous heart failure (DHF), cardiac conduction abnormalities cause the regional distribution of myocardial work to be non-homogeneous. Cardiac resynchronization therapy (CRT) using an implantable, programmed biventricular pacemaker/defibrillator, can improve the synchrony of...

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Main Authors: Amanda Craine, Adarsh Krishnamurthy, Christopher T Villongco, Kevin Vincent, David E Krummen, Sanjiv M Narayan, Roy C P Kerckhoffs, Jeffrey H Omens, Francisco Contijoch, Andrew D McCulloch
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2024-10-01
Series:PLoS Computational Biology
Online Access:https://doi.org/10.1371/journal.pcbi.1012150
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https://doi.org/10.1371/journal.pcbi.1012150

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