Comparison of Illumina and Oxford Nanopore sequencing data quality for Clostridioides difficile genome analysis and their application for epidemiological surveillance

Comparison of Illumina and Oxford Nanopore sequencing data quality for Clostridioides difficile genome analysis and their application for epidemiological surveillance

Abstract Background The burden of Clostridioides difficile as a nosocomial- and community-acquired pathogen has been increasing over the recent decades, including reports of severe outbreaks. Molecular and virulence genotyping are central for the epidemiological surveillance of this pathogen, but ne...

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Main Authors: Semeh Bejaoui, Sofie Holtsmark Nielsen, Astrid Rasmussen, John Eugenio Coia, Dorte Terp Andersen, Tobias Bruun Pedersen, Martin Vad Møller, Marc Trunjer Kusk Nielsen, Dorte Frees, Søren Persson
Format: Article
Language:English
Published: BMC 2025-01-01
Series:BMC Genomics
Subjects:
Clostridioides difficile
Whole genome sequencing (WGS)
Illumina
Oxford Nanopore
Epidemiological surveillance
Genotyping
Online Access:https://doi.org/10.1186/s12864-025-11267-9
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https://doi.org/10.1186/s12864-025-11267-9

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