Simultaneous Determination and Pharmacokinetic Comparisons of Multi-Ingredients after Oral Administration of Radix Salviae Miltiorrhizae Extract, Hawthorn Extract, and a Combination of Both Extracts to Rats
A simple and sensitive HPLC method was developed for simultaneous determination of danshensu (DSS), rosmarinic acid (RA), lithospermic acid (LA), salvianolic acid B (SAB), and hyperoside (HP) in rat plasma. This method validated was successfully applied to the pharmacokinetic study of the main activ...
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| Format: | Article |
| Language: | English |
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Wiley
2014-01-01
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| Series: | Journal of Analytical Methods in Chemistry |
| Online Access: | http://dx.doi.org/10.1155/2014/617367 |
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| author | Yu-Qiang Liu Qian Cai Chang Liu Feng-Wei Bao Zhen-Qiu Zhang |
| author_facet | Yu-Qiang Liu Qian Cai Chang Liu Feng-Wei Bao Zhen-Qiu Zhang |
| author_sort | Yu-Qiang Liu |
| collection | DOAJ |
| description | A simple and sensitive HPLC method was developed for simultaneous determination of danshensu (DSS), rosmarinic acid (RA), lithospermic acid (LA), salvianolic acid B (SAB), and hyperoside (HP) in rat plasma. This method validated was successfully applied to the pharmacokinetic study of the main active ingredients after oral administration of Radix Salviae Miltiorrhizae extract (SME), hawthorn extract (HTE), and a combination of both extracts (2.5 : 1) to rats. The results indicated that there have been great differences in pharmacokinetics between a single extract and a combination of both extracts. A combination of both extracts can enhance their bioavailabilities and delay the elimination of SAB and DSS in rats. |
| format | Article |
| id | doaj-art-e4c1adeac30d4eb7a42d308c9664e697 |
| institution | Kabale University |
| issn | 2090-8865 2090-8873 |
| language | English |
| publishDate | 2014-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Analytical Methods in Chemistry |
| spelling | doaj-art-e4c1adeac30d4eb7a42d308c9664e6972025-02-03T01:10:23ZengWileyJournal of Analytical Methods in Chemistry2090-88652090-88732014-01-01201410.1155/2014/617367617367Simultaneous Determination and Pharmacokinetic Comparisons of Multi-Ingredients after Oral Administration of Radix Salviae Miltiorrhizae Extract, Hawthorn Extract, and a Combination of Both Extracts to RatsYu-Qiang Liu0Qian Cai1Chang Liu2Feng-Wei Bao3Zhen-Qiu Zhang4School of Medicine, Liaoning University of Traditional Chinese Medicine, Dalian 116600, ChinaSchool of Medicine, Liaoning University of Traditional Chinese Medicine, Dalian 116600, ChinaSchool of Medicine, Liaoning University of Traditional Chinese Medicine, Dalian 116600, ChinaSchool of Medicine, Liaoning University of Traditional Chinese Medicine, Dalian 116600, ChinaSchool of Medicine, Liaoning University of Traditional Chinese Medicine, Dalian 116600, ChinaA simple and sensitive HPLC method was developed for simultaneous determination of danshensu (DSS), rosmarinic acid (RA), lithospermic acid (LA), salvianolic acid B (SAB), and hyperoside (HP) in rat plasma. This method validated was successfully applied to the pharmacokinetic study of the main active ingredients after oral administration of Radix Salviae Miltiorrhizae extract (SME), hawthorn extract (HTE), and a combination of both extracts (2.5 : 1) to rats. The results indicated that there have been great differences in pharmacokinetics between a single extract and a combination of both extracts. A combination of both extracts can enhance their bioavailabilities and delay the elimination of SAB and DSS in rats.http://dx.doi.org/10.1155/2014/617367 |
| spellingShingle | Yu-Qiang Liu Qian Cai Chang Liu Feng-Wei Bao Zhen-Qiu Zhang Simultaneous Determination and Pharmacokinetic Comparisons of Multi-Ingredients after Oral Administration of Radix Salviae Miltiorrhizae Extract, Hawthorn Extract, and a Combination of Both Extracts to Rats Journal of Analytical Methods in Chemistry |
| title | Simultaneous Determination and Pharmacokinetic Comparisons of Multi-Ingredients after Oral Administration of Radix Salviae Miltiorrhizae Extract, Hawthorn Extract, and a Combination of Both Extracts to Rats |
| title_full | Simultaneous Determination and Pharmacokinetic Comparisons of Multi-Ingredients after Oral Administration of Radix Salviae Miltiorrhizae Extract, Hawthorn Extract, and a Combination of Both Extracts to Rats |
| title_fullStr | Simultaneous Determination and Pharmacokinetic Comparisons of Multi-Ingredients after Oral Administration of Radix Salviae Miltiorrhizae Extract, Hawthorn Extract, and a Combination of Both Extracts to Rats |
| title_full_unstemmed | Simultaneous Determination and Pharmacokinetic Comparisons of Multi-Ingredients after Oral Administration of Radix Salviae Miltiorrhizae Extract, Hawthorn Extract, and a Combination of Both Extracts to Rats |
| title_short | Simultaneous Determination and Pharmacokinetic Comparisons of Multi-Ingredients after Oral Administration of Radix Salviae Miltiorrhizae Extract, Hawthorn Extract, and a Combination of Both Extracts to Rats |
| title_sort | simultaneous determination and pharmacokinetic comparisons of multi ingredients after oral administration of radix salviae miltiorrhizae extract hawthorn extract and a combination of both extracts to rats |
| url | http://dx.doi.org/10.1155/2014/617367 |
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