β-Catenin Regulation in Sporadic Colorectal Carcinogenesis: Not as Simple as APC

Background. The wnt/APC/β-catenin pathway is a critical initiator in colorectal carcinogenesis in both hereditary and sporadic colorectal cancer (CRC). The progression of this process remains incompletely understood, although inflammation is pivotal. Drivers of inflammation are elevated in malignant...

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Bibliographic Details
Main Authors: Ernst Fredericks, Gill Dealtry, Saartjie Roux
Format: Article
Language:English
Published: Wiley 2018-01-01
Series:Canadian Journal of Gastroenterology and Hepatology
Online Access:http://dx.doi.org/10.1155/2018/4379673
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