The Role of Trifluoromethyl and Trifluoromethoxy Groups in Medicinal Chemistry: Implications for Drug Design

The Role of Trifluoromethyl and Trifluoromethoxy Groups in Medicinal Chemistry: Implications for Drug Design

One of the key strategies in drug design involves modifying molecular scaffolds with specific chemical groups, or side chains, to enhance biological and physicochemical properties. These modifications can strengthen interactions with biological targets or improve pharmacokinetic and physicochemical...

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Bibliographic Details
Main Authors: Manuel Novás, Maria J. Matos
Format: Article
Language:English
Published: MDPI AG 2025-07-01
Series:Molecules
Subjects:
trifluoromethyl group
trifluoromethoxy group
drug design
medicinal chemistry
Online Access:https://www.mdpi.com/1420-3049/30/14/3009
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