A comparison of SWATH-MS methods for measurement of residual host cell proteins in adeno-associated virus preparations

IntroductionAnalysis of residual host cell proteins in adeno-associated virus (AAV) preparations is challenging due to low availability and high complexity of samples. One strategy to address these challenges is through development of improved liquid chromatography-tandem mass spectrometry (LC-MS/MS...

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Bibliographic Details
Main Authors: Thomas M. Leibiger, Lie Min, Kelvin H. Lee
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-05-01
Series:Frontiers in Bioengineering and Biotechnology
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Online Access:https://www.frontiersin.org/articles/10.3389/fbioe.2025.1579098/full
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