Structural and functional thalamic alterations in major depressive disorder with comorbid chronic pain

Structural and functional thalamic alterations in major depressive disorder with comorbid chronic pain

Abstract Major Depressive Disorder (MDD) is a prevalent mental health condition, often accompanied by chronic pain. This study investigates the structural and functional characteristics of the thalamus in individuals with MDD, both with and without comorbid pain, using magnetic resonance imaging (MR...

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Bibliographic Details
Main Authors: Jinzhong Ye, Caixia Xu, Huagui Guo, Wei Huang, Guojun Xie, Jiaquan Liang
Format: Article
Language:English
Published: Nature Portfolio 2025-05-01
Series:Scientific Reports
Subjects:
Major depressive disorder
Thalamus
Chronic pain
Neuroimaging
Fractional amplitude of low-frequency fluctuations (fALFF)
Regional homogeneity (ReHo)
Online Access:https://doi.org/10.1038/s41598-025-00431-6
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