Knocking Down the DRD2 by shRNA Expressing Plasmids in the Nucleus Accumbens Prevented the Disrupting Effect of Apomorphine on Prepulse Inhibition in Rat

Knocking Down the DRD2 by shRNA Expressing Plasmids in the Nucleus Accumbens Prevented the Disrupting Effect of Apomorphine on Prepulse Inhibition in Rat

Prepulse Inhibition (PPI), the objective measure of sensorimotor gating disturbance has being widely used in animal models of schizophrenia. Dopaminergic direct and indirect agonists impair PPI. However, the profile of dopaminergic receptors involved in PPI impairment by dopamine agonists is not cle...

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Main Authors: M.R. Noori-daloii, A. Shahbazi, S. Alizadeh Zendehrood, A. Shayan Nia, M. Mojarrad, M. Kheirollahi, A. Rashidi-Nezhad, A. Haghparast, F. Zare Mehrjerdi, S. Niknazar, M. Mostowfi, H. Hashemi Sotoobadi, M. Khaksari, A. R. Noori-Daloii, A. Mohammadi
Format: Article
Language:English
Published: University of Tehran 2015-09-01
Series:Journal of Sciences, Islamic Republic of Iran
Subjects:
shrna
drd2
nucleus accumbens
schizophrenia
prepulse inhibition
Online Access:https://jsciences.ut.ac.ir/article_55308_eb4b1150fb252aa03c8ffd6d54239943.pdf
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https://jsciences.ut.ac.ir/article_55308_eb4b1150fb252aa03c8ffd6d54239943.pdf

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