Mitochondrial calcium uniporter promotes MSU crystal-induced inflammation through inducing mitochondrial Ca2+ overload and ubiquitination of SIRT5 protein

Mitochondrial calcium uniporter promotes MSU crystal-induced inflammation through inducing mitochondrial Ca2+ overload and ubiquitination of SIRT5 protein

Abstract Background The mitochondrial calcium uniporter (MCU) is the key channel regulating mitochondrial calcium (Ca²⁺) uptake. Growing evidence indicates that mitochondrial Ca²⁺ homeostasis plays a pivotal role in regulating immune cell function. However, how MCU contributes to MSU crystal-driven...

Full description

Saved in:
Bibliographic Details
Main Authors: Qingqing Yu, Renjie Li, Guizhao Yang, Yan Xiao, Xingyu Liu, Yaxin Deng, Xiongyan Luo, Qian Dai, Mei Zeng
Format: Article
Language:English
Published: BMC 2025-08-01
Series:Arthritis Research & Therapy
Subjects:
MCU
MSU crystals
Mitochondrial Ca2+
TRIM21
SIRT5
Online Access:https://doi.org/10.1186/s13075-025-03627-3
Tags: Add Tag
No Tags, Be the first to tag this record!

Internet

https://doi.org/10.1186/s13075-025-03627-3

Similar Items