Biomimetic polymersomal nanoreactors for hepatocyte-directed detoxification in drug-induced liver injury
Drug-induced liver injury (DILI) is a major clinical concern associated with drug toxicity, primarily characterized by hepatocyte damage driven by oxidative stress and inflammation. Excessive accumulation of reactive oxygen species (ROS) and pro-inflammatory cytokines exacerbates liver injury, neces...
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Elsevier
2025-10-01
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| Series: | Materials Today Bio |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2590006425007392 |
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| author | Wenxing Gu Ruxue Bai Jiaxin Wang Jun Wang Chongzhou Fang Yuanchao Shi Peixing Wang Qiaoqiao Wang Wei Bing Tian Xie Jing Mu |
| author_facet | Wenxing Gu Ruxue Bai Jiaxin Wang Jun Wang Chongzhou Fang Yuanchao Shi Peixing Wang Qiaoqiao Wang Wei Bing Tian Xie Jing Mu |
| author_sort | Wenxing Gu |
| collection | DOAJ |
| description | Drug-induced liver injury (DILI) is a major clinical concern associated with drug toxicity, primarily characterized by hepatocyte damage driven by oxidative stress and inflammation. Excessive accumulation of reactive oxygen species (ROS) and pro-inflammatory cytokines exacerbates liver injury, necessitating effective therapeutic interventions. While natural antioxidant enzymes exhibit high catalytic activity and specificity in ROS scavenging, their clinical use is limited by poor stability in circulation and limited cellular uptake. To address these challenges, we developed antioxidant polymersomal nanoreactors (CS@PS) for the targeted co-delivery of catalase (CAT) and superoxide dismutase (SOD). CS@PS functions as a cascade system, efficiently neutralizing ROS and mitigating inflammation in hepatocytes. Notably, systemic administration of CS@PS exhibits targeted delivery to hepatocytes, ensuring enzyme stability and bioavailability. In a model of acetaminophen-induced liver injury, CS@PS significantly reduced hepatic ROS levels and alleviated liver damage, underscoring its therapeutic potential. This study highlights the promise of CS@PS as an innovative antioxidant nanoreactor for DILI treatment offer a promising strategy for managing other ROS-mediated diseases. |
| format | Article |
| id | doaj-art-e422348d86204dc382db6872cc90df56 |
| institution | DOAJ |
| issn | 2590-0064 |
| language | English |
| publishDate | 2025-10-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Materials Today Bio |
| spelling | doaj-art-e422348d86204dc382db6872cc90df562025-08-20T02:57:22ZengElsevierMaterials Today Bio2590-00642025-10-013410216910.1016/j.mtbio.2025.102169Biomimetic polymersomal nanoreactors for hepatocyte-directed detoxification in drug-induced liver injuryWenxing Gu0Ruxue Bai1Jiaxin Wang2Jun Wang3Chongzhou Fang4Yuanchao Shi5Peixing Wang6Qiaoqiao Wang7Wei Bing8Tian Xie9Jing Mu10Institute of Precision Medicine, Peking University Shenzhen Hospital, Shenzhen, 518036, China; School of Pharmacy, Zhejiang Provincial Key Laboratory of Anti-Cancer Chinese Medicines and Natural Medicines, Hangzhou Normal University, Hangzhou, 311121, ChinaInstitute of Precision Medicine, Peking University Shenzhen Hospital, Shenzhen, 518036, China; School of Chemistry and Life Science, Changchun University of Technology, Changchun, 130012, ChinaInstitute of Precision Medicine, Peking University Shenzhen Hospital, Shenzhen, 518036, ChinaInstitute of Precision Medicine, Peking University Shenzhen Hospital, Shenzhen, 518036, ChinaInstitute of Precision Medicine, Peking University Shenzhen Hospital, Shenzhen, 518036, ChinaInstitute of Precision Medicine, Peking University Shenzhen Hospital, Shenzhen, 518036, ChinaSchool of Pharmacy, Zhejiang Provincial Key Laboratory of Anti-Cancer Chinese Medicines and Natural Medicines, Hangzhou Normal University, Hangzhou, 311121, ChinaSchool of Pharmacy, Zhejiang Provincial Key Laboratory of Anti-Cancer Chinese Medicines and Natural Medicines, Hangzhou Normal University, Hangzhou, 311121, ChinaSchool of Chemistry and Life Science, Changchun University of Technology, Changchun, 130012, China; Key Laboratory of Bionic Engineering, Ministry of Education, Jilin University, Changchun, 130022, China; Corresponding author. School of Chemistry and Life Science, Changchun University of Technology, Changchun, 130012, ChinaSchool of Pharmacy, Zhejiang Provincial Key Laboratory of Anti-Cancer Chinese Medicines and Natural Medicines, Hangzhou Normal University, Hangzhou, 311121, China; Corresponding author.Institute of Precision Medicine, Peking University Shenzhen Hospital, Shenzhen, 518036, China; Corresponding author.Drug-induced liver injury (DILI) is a major clinical concern associated with drug toxicity, primarily characterized by hepatocyte damage driven by oxidative stress and inflammation. Excessive accumulation of reactive oxygen species (ROS) and pro-inflammatory cytokines exacerbates liver injury, necessitating effective therapeutic interventions. While natural antioxidant enzymes exhibit high catalytic activity and specificity in ROS scavenging, their clinical use is limited by poor stability in circulation and limited cellular uptake. To address these challenges, we developed antioxidant polymersomal nanoreactors (CS@PS) for the targeted co-delivery of catalase (CAT) and superoxide dismutase (SOD). CS@PS functions as a cascade system, efficiently neutralizing ROS and mitigating inflammation in hepatocytes. Notably, systemic administration of CS@PS exhibits targeted delivery to hepatocytes, ensuring enzyme stability and bioavailability. In a model of acetaminophen-induced liver injury, CS@PS significantly reduced hepatic ROS levels and alleviated liver damage, underscoring its therapeutic potential. This study highlights the promise of CS@PS as an innovative antioxidant nanoreactor for DILI treatment offer a promising strategy for managing other ROS-mediated diseases.http://www.sciencedirect.com/science/article/pii/S2590006425007392Hepatocyte targetingPolymersomeNanoreactorDrug-induced liver injuryReactive oxygen species |
| spellingShingle | Wenxing Gu Ruxue Bai Jiaxin Wang Jun Wang Chongzhou Fang Yuanchao Shi Peixing Wang Qiaoqiao Wang Wei Bing Tian Xie Jing Mu Biomimetic polymersomal nanoreactors for hepatocyte-directed detoxification in drug-induced liver injury Materials Today Bio Hepatocyte targeting Polymersome Nanoreactor Drug-induced liver injury Reactive oxygen species |
| title | Biomimetic polymersomal nanoreactors for hepatocyte-directed detoxification in drug-induced liver injury |
| title_full | Biomimetic polymersomal nanoreactors for hepatocyte-directed detoxification in drug-induced liver injury |
| title_fullStr | Biomimetic polymersomal nanoreactors for hepatocyte-directed detoxification in drug-induced liver injury |
| title_full_unstemmed | Biomimetic polymersomal nanoreactors for hepatocyte-directed detoxification in drug-induced liver injury |
| title_short | Biomimetic polymersomal nanoreactors for hepatocyte-directed detoxification in drug-induced liver injury |
| title_sort | biomimetic polymersomal nanoreactors for hepatocyte directed detoxification in drug induced liver injury |
| topic | Hepatocyte targeting Polymersome Nanoreactor Drug-induced liver injury Reactive oxygen species |
| url | http://www.sciencedirect.com/science/article/pii/S2590006425007392 |
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