Biomimetic polymersomal nanoreactors for hepatocyte-directed detoxification in drug-induced liver injury

Biomimetic polymersomal nanoreactors for hepatocyte-directed detoxification in drug-induced liver injury

Drug-induced liver injury (DILI) is a major clinical concern associated with drug toxicity, primarily characterized by hepatocyte damage driven by oxidative stress and inflammation. Excessive accumulation of reactive oxygen species (ROS) and pro-inflammatory cytokines exacerbates liver injury, neces...

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Bibliographic Details
Main Authors: Wenxing Gu, Ruxue Bai, Jiaxin Wang, Jun Wang, Chongzhou Fang, Yuanchao Shi, Peixing Wang, Qiaoqiao Wang, Wei Bing, Tian Xie, Jing Mu
Format: Article
Language:English
Published: Elsevier 2025-10-01
Series:Materials Today Bio
Subjects:
Hepatocyte targeting
Polymersome
Nanoreactor
Drug-induced liver injury
Reactive oxygen species
Online Access:http://www.sciencedirect.com/science/article/pii/S2590006425007392
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