CD2AP at the junction of nephropathy and Alzheimer’s disease

CD2AP at the junction of nephropathy and Alzheimer’s disease

Abstract Polymorphisms in the gene encoding CD2-associated protein (CD2AP) are associated with an increased risk for developing Alzheimer’s disease (AD). Intriguingly, variants in the gene also cause a pattern of kidney injury termed focal segmental glomerulosclerosis. Recent studies have investigat...

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Bibliographic Details
Main Authors: Milene Vandal, Mohsen Janmaleki, Isabel Rea, Colin Gunn, Sotaro Hirai, Jeff Biernaskie, Justin Chun, Grant Gordon, Andrey Shaw, Amir Sanati-Nezhad, Gerald Pfeffer, Frederic Calon, Minh Dang Nguyen
Format: Article
Language:English
Published: BMC 2025-06-01
Series:Molecular Neurodegeneration
Subjects:
CD2AP
Alzheimer
Kidney-brain axis
Brain-body interactions
Neurodegeneration
Sexual dimorphism
Online Access:https://doi.org/10.1186/s13024-025-00852-x
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https://doi.org/10.1186/s13024-025-00852-x

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