OTUB1 promotes colorectal cancer progression by stabilizing GPX4 and inhibiting ferroptosis

OTUB1 promotes colorectal cancer progression by stabilizing GPX4 and inhibiting ferroptosis

Abstract Background Therapeutic resistance in colorectal cancer (CRC) is frequently linked to dysregulated protein homeostasis, which enables tumor cells to evade cell death. The ubiquitin-proteasome system (UPS) plays a pivotal role in regulating protein stability and has been implicated in ferropt...

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Bibliographic Details
Main Authors: Guofeng Lin, Xi Lin, Qihuang Lin, Jianfeng Zhao
Format: Article
Language:English
Published: Springer 2025-07-01
Series:Discover Oncology
Subjects:
Colorectal cancer
OTUB1
GPX4
Ferroptosis
Ubiquitination
Therapeutic target
Online Access:https://doi.org/10.1007/s12672-025-03022-z
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https://doi.org/10.1007/s12672-025-03022-z

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