Integrated Single-Cell Analysis Revealed Novel Subpopulations of Foamy Macrophages in Human Atherosclerotic Plaques

Integrated Single-Cell Analysis Revealed Novel Subpopulations of Foamy Macrophages in Human Atherosclerotic Plaques

Foam cell formation is a hallmark of atherosclerosis, yet the cellular complexity within foam cells in human plaques remains unexplored. Here, we integrate published single-cell RNA-sequencing, spatial transcriptomic, and chromatin accessibility sequencing datasets of human atherosclerotic lesions a...

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Bibliographic Details
Main Authors: Yunrui Lu, Shuang Wu, Shiyu Zhu, Jian Shen, Chang Liu, Chaoyue Zhao, Sheng’an Su, Hong Ma, Meixiang Xiang, Yao Xie
Format: Article
Language:English
Published: MDPI AG 2024-12-01
Series:Biomolecules
Subjects:
atherosclerosis
foam cells
macrophages
integrated single-cell analysis
single-cell RNA sequencing
Mendelian randomization
Online Access:https://www.mdpi.com/2218-273X/14/12/1606
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https://www.mdpi.com/2218-273X/14/12/1606

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