Skeletal editing of 4-arylpyrimidines into diverse nitrogen heteroaromatics via four-atom synthons

Skeletal editing of 4-arylpyrimidines into diverse nitrogen heteroaromatics via four-atom synthons

Abstract Scaffold hopping is a key strategy in drug discovery. While one-to-one scaffold hopping strategies are thriving and evolving, one-to-multiple strategies remain challenging to design. We present here a distinct scaffold hopping strategy for the skeletal editing of pyrimidines into a wide ran...

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Main Authors: Shun Li, Yonglin Shi, Juan Tang, Meixin Yan, Shunyao Huang, Tingying Dou, Shenxiang Wang, Xinchao Jin, Zhishan Su, Weidong Jiang, Jiaqi Xu, Xueli Zheng, Ruixiang Li, Hua Chen, Weichao Xue, Haiyan Fu
Format: Article
Language:English
Published: Nature Portfolio 2025-08-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-025-62547-7
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https://doi.org/10.1038/s41467-025-62547-7

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