In Situ Microscopy with Real-Time Image Analysis Enables Online Monitoring of Technical Protein Crystallization Kinetics in Stirred Crystallizers

In Situ Microscopy with Real-Time Image Analysis Enables Online Monitoring of Technical Protein Crystallization Kinetics in Stirred Crystallizers

Controlling protein crystallization processes is essential for improving downstream processing in biotechnology. This study investigates the combination of machine learning-based image analysis and in situ microscopy for real-time monitoring of protein crystallization kinetics. The experimental rese...

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Bibliographic Details
Main Authors: Julian Mentges, Daniel Bischoff, Brigitte Walla, Dirk Weuster-Botz
Format: Article
Language:English
Published: MDPI AG 2024-11-01
Series:Crystals
Subjects:
technical protein crystallization
crystal image analysis
downstream processing
protein aggregate formation
crystal growth kinetics
Online Access:https://www.mdpi.com/2073-4352/14/12/1009
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https://www.mdpi.com/2073-4352/14/12/1009

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