Characterization of VSV-GP morphology by cryo-EM imaging and SEC-MALS

Characterization of VSV-GP morphology by cryo-EM imaging and SEC-MALS

Vesicular stomatitis virus expressing the glycoprotein of the lymphocytic choriomeningitis virus (VSV-GP) is a promising platform for oncolytic viruses and cancer vaccines. In this work, cryoelectron microscopy (cryo-EM) imaging was employed to directly visualize VSV-GP particles. Several different...

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Main Authors: Dongyue Xin, Leela Kurien, Katherine Briggs, Adrian Schimek, Richard Dambra, Daniel Hochdorfer, Tanja A. Arnouk, Marija Brgles, Saurabh Gautam, Dominik Hotter, Johannes Solzin, Thomas Kriehuber, Joseph Ashour, Adam Vigil, Michael Hawley, Xiaorong He
Format: Article
Language:English
Published: Elsevier 2025-03-01
Series:Molecular Therapy: Methods & Clinical Development
Subjects:
vesicular stomatitis virus
VSV-GP
virus particle morphology
cryo-EM
SEC-MALS
analytical HPLC
Online Access:http://www.sciencedirect.com/science/article/pii/S2329050125000245
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