Asymmetrically PEGylated and amphipathic heptamethine indocyanine dyes potentiate radiotherapy of renal cell carcinoma via mitochondrial targeting

Abstract Enhancing the sensitivity of radiotherapy (RT) towards renal cell carcinoma (RCC) remains a challenge because RCC is a radioresistant tumor. In this work, we design and report asymmetrically Polyethylene Glycol (PEG)ylated and amphipathic heptamethine indocyanine dyes for efficient radiosen...

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Bibliographic Details
Main Authors: Zifei Wu, Xie Huang, Chuan Wu, Yan Zhou, Mingquan Gao, Shenglin Luo, Qiang Xiang, Weidong Wang, Rong Li
Format: Article
Language:English
Published: BMC 2024-12-01
Series:Journal of Nanobiotechnology
Subjects:
Online Access:https://doi.org/10.1186/s12951-024-03012-3
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