Performance of molecular inversion probe DR23K and Paragon MAD4HatTeR Amplicon sequencing panels for detection of Plasmodium falciparum mutations associated with antimalarial drug resistance

Performance of molecular inversion probe DR23K and Paragon MAD4HatTeR Amplicon sequencing panels for detection of Plasmodium falciparum mutations associated with antimalarial drug resistance

Abstract Background Molecular surveillance of drug-resistant Plasmodium falciparum is crucial for malaria control in endemic regions. Two targeted-resequencing tools, the Molecular Inversion Probe (MIP) drug resistance panel DR23K and the Multiplexed Amplicons for Drugs, Diagnostics, Diversity, and...

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Main Authors: Thomas Katairo, Victor Asua, Bienvenu Nsengimaana, Stephen Tukwasibwe, Francis D. Semakuba, Innocent Wiringilimaana, Brian A. Kagurusi, Caroline Mwubaha, Jackie Nakasaanya, Shreeya Garg, Shahiid Kiyaga, Monica Mbabazi, Kisakye D. Kabbale, Alisen Ayitewala, Samuel L. Nsobya, Moses R. Kamya, Isaac Ssewanyana, Jeffrey A. Bailey, Andrés Aranda-Díaz, Philip J. Rosenthal, Bryan Greenhouse, Jessica Briggs, Melissa D. Conrad
Format: Article
Language:English
Published: BMC 2025-06-01
Series:Malaria Journal
Subjects:
Antimalarial drug resistance
MAD4HatTeR
DR23K
Molecular inversion probes
SNPs
Microhaplotypes
Online Access:https://doi.org/10.1186/s12936-025-05441-3
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https://doi.org/10.1186/s12936-025-05441-3

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