Inhibition of the SR protein-phosphorylating CLK kinases of Plasmodium falciparum impairs blood stage replication and malaria transmission.

Inhibition of the SR protein-phosphorylating CLK kinases of Plasmodium falciparum impairs blood stage replication and malaria transmission.

Cyclin-dependent kinase-like kinases (CLKs) are dual specificity protein kinases that phosphorylate Serine/Arginine-rich (SR) proteins involved in pre-mRNA processing. Four CLKs, termed PfCLK-1-4, can be identified in the human malaria parasite Plasmodium falciparum, which show homology with the yea...

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Main Authors: Selina Kern, Shruti Agarwal, Kilian Huber, André P Gehring, Benjamin Strödke, Christine C Wirth, Thomas Brügl, Liliane Onambele Abodo, Thomas Dandekar, Christian Doerig, Rainer Fischer, Andrew B Tobin, Mahmood M Alam, Franz Bracher, Gabriele Pradel
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:https://doi.org/10.1371/journal.pone.0105732
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https://doi.org/10.1371/journal.pone.0105732

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