RAPTOR: Randomised Controlled Trial of PENTOCLO (pentoxifylline-tocopherol-clodronate) in Mandibular Osteoradionecrosis—study protocol for an open-label phase II randomised controlled superiority trial

RAPTOR: Randomised Controlled Trial of PENTOCLO (pentoxifylline-tocopherol-clodronate) in Mandibular Osteoradionecrosis—study protocol for an open-label phase II randomised controlled superiority trial

Abstract Background Mandibular osteoradionecrosis (ORN) is a severe late radiation toxicity affecting 5–10% of patients who receive radiotherapy as part of treatment for head and neck malignancy. ORN can cause permanent disfigurement, dysfunction, pain and infection. There remains little robust evid...

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Main Authors: Richard Shaw, Ruth Knight, Ayten Basoglu, Mandeep Bajwa, Julie Perry, Anastasios Kanatas, Stefano Fedele, Vincent Killen, Rebecca Tangney, Chris Butterworth, James McCaul, Jagtar Dhanda, Vinod Patel, Mererid Evans, Richard Jackson
Format: Article
Language:English
Published: BMC 2025-07-01
Series:Trials
Subjects:
Mandible
Osteoradionecrosis
Radiotherapy
Head and neck
Cancer
PENTOCLO
Online Access:https://doi.org/10.1186/s13063-025-08966-9
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https://doi.org/10.1186/s13063-025-08966-9

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