4E10-resistant HIV-1 isolated from four subjects with rare membrane-proximal external region polymorphisms.

4E10-resistant HIV-1 isolated from four subjects with rare membrane-proximal external region polymorphisms.

Human antibody 4E10 targets the highly conserved membrane-proximal external region (MPER) of the HIV-1 transmembrane glycoprotein, gp41, and has extraordinarily broad neutralizing activity. It is considered by many to be a prototype for vaccine development. In this study, we describe four subjects i...

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Main Authors: Kyle J Nakamura, Johannes S Gach, Laura Jones, Katherine Semrau, Jan Walter, Frederic Bibollet-Ruche, Julie M Decker, Laura Heath, William D Decker, Moses Sinkala, Chipepo Kankasa, Donald Thea, James Mullins, Louise Kuhn, Michael B Zwick, Grace M Aldrovandi
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2010-03-01
Series:PLoS ONE
Online Access:https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0009786&type=printable
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https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0009786&type=printable

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