The Role of Purinergic Receptors in Cancer-Induced Bone Pain
Cancer-induced bone pain severely compromises the quality of life of many patients suffering from bone metastasis, as current therapies leave some patients with inadequate pain relief. The recent development of specific animal models has increased the understanding of the molecular and cellular mech...
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| Format: | Article |
| Language: | English |
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Wiley
2012-01-01
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| Series: | Journal of Osteoporosis |
| Online Access: | http://dx.doi.org/10.1155/2012/758181 |
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| author | Sarah Falk Maria Uldall Anne-Marie Heegaard |
| author_facet | Sarah Falk Maria Uldall Anne-Marie Heegaard |
| author_sort | Sarah Falk |
| collection | DOAJ |
| description | Cancer-induced bone pain severely compromises the quality of life of many patients suffering from bone metastasis, as current therapies leave some patients with inadequate pain relief. The recent development of specific animal models has increased the understanding of the molecular and cellular mechanisms underlying cancer-induced bone pain including the involvement of ATP and the purinergic receptors in the progression of the pain state. In nociception, ATP acts as an extracellular messenger to transmit sensory information both at the peripheral site of tissue damage and in the spinal cord. Several of the purinergic receptors have been shown to be important for the development and maintenance of neuropathic and inflammatory pain, and studies have demonstrated the importance of both peripheral and central mechanisms. We here provide an overview of the current literature on the role of purinergic receptors in cancer-induced bone pain with emphasis on some of the difficulties related to studying this complex pain state. |
| format | Article |
| id | doaj-art-e37f26d873c649ce85e3343561d503bc |
| institution | Kabale University |
| issn | 2090-8059 2042-0064 |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Osteoporosis |
| spelling | doaj-art-e37f26d873c649ce85e3343561d503bc2025-02-03T01:11:56ZengWileyJournal of Osteoporosis2090-80592042-00642012-01-01201210.1155/2012/758181758181The Role of Purinergic Receptors in Cancer-Induced Bone PainSarah Falk0Maria Uldall1Anne-Marie Heegaard2Department of Drug Design and Pharmacology, Faculty of Health and Medical Sciences, University of Copenhagen, 2100 Copenhagen, DenmarkDepartment of Drug Design and Pharmacology, Faculty of Health and Medical Sciences, University of Copenhagen, 2100 Copenhagen, DenmarkDepartment of Drug Design and Pharmacology, Faculty of Health and Medical Sciences, University of Copenhagen, 2100 Copenhagen, DenmarkCancer-induced bone pain severely compromises the quality of life of many patients suffering from bone metastasis, as current therapies leave some patients with inadequate pain relief. The recent development of specific animal models has increased the understanding of the molecular and cellular mechanisms underlying cancer-induced bone pain including the involvement of ATP and the purinergic receptors in the progression of the pain state. In nociception, ATP acts as an extracellular messenger to transmit sensory information both at the peripheral site of tissue damage and in the spinal cord. Several of the purinergic receptors have been shown to be important for the development and maintenance of neuropathic and inflammatory pain, and studies have demonstrated the importance of both peripheral and central mechanisms. We here provide an overview of the current literature on the role of purinergic receptors in cancer-induced bone pain with emphasis on some of the difficulties related to studying this complex pain state.http://dx.doi.org/10.1155/2012/758181 |
| spellingShingle | Sarah Falk Maria Uldall Anne-Marie Heegaard The Role of Purinergic Receptors in Cancer-Induced Bone Pain Journal of Osteoporosis |
| title | The Role of Purinergic Receptors in Cancer-Induced Bone Pain |
| title_full | The Role of Purinergic Receptors in Cancer-Induced Bone Pain |
| title_fullStr | The Role of Purinergic Receptors in Cancer-Induced Bone Pain |
| title_full_unstemmed | The Role of Purinergic Receptors in Cancer-Induced Bone Pain |
| title_short | The Role of Purinergic Receptors in Cancer-Induced Bone Pain |
| title_sort | role of purinergic receptors in cancer induced bone pain |
| url | http://dx.doi.org/10.1155/2012/758181 |
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