High-affinity agonists reveal recognition motifs for the MRGPRD GPCR

High-affinity agonists reveal recognition motifs for the MRGPRD GPCR

Summary: The human MRGPRD protein is a member of the Mas-related G protein-coupled receptors (MRGPRs) that is involved in the sensing of pain, itch, and other inflammatory stimuli. As with other MRGPRs, MRGPRD is a relatively understudied receptor with few known agonists. The most potent small-molec...

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Main Authors: Chunyu Wang, Yongfeng Liu, Marion Lanier, Adam Yeager, Isha Singh, Ryan H. Gumpper, Brian E. Krumm, Chelsea DeLeon, Shicheng Zhang, Marcus Boehm, Richard Pittner, Alain Baron, Lisa Dvorak, Corinne Bacon, Brian K. Shoichet, Esther Martinborough, Jonathan F. Fay, Can Cao, Bryan L. Roth
Format: Article
Language:English
Published: Elsevier 2024-12-01
Series:Cell Reports
Subjects:
CP: Molecular biology
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124724012932
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http://www.sciencedirect.com/science/article/pii/S2211124724012932

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