Metformin modulates oxidative stress via activation of AMPK/NF-κB signaling in Trisomy 21 fibroblasts: an in vitro study

Metformin modulates oxidative stress via activation of AMPK/NF-κB signaling in Trisomy 21 fibroblasts: an in vitro study

IntroductionOxidative stress and impaired antioxidant defenses are key contributors to cellular dysfunction in Trisomy 21 (T21), highlighting the need for targeted therapeutic strategies. This study explores the modulatory effects of metformin on oxidative stress and antioxidant capacity in T21.Meth...

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Bibliographic Details
Main Authors: Angelika Buczyńska, Piotr Malinowski, Arkadiusz Żbikowski, Adam Jacek Krętowski, Monika Zbucka-Krętowska
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-06-01
Series:Frontiers in Molecular Biosciences
Subjects:
Trisomy 21
oxidative stress
metformin
Transcription factors
antioxidant capacity
Online Access:https://www.frontiersin.org/articles/10.3389/fmolb.2025.1577044/full
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https://www.frontiersin.org/articles/10.3389/fmolb.2025.1577044/full

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