Developmental and molecular effects of pure-tone sine wave exposure on early zebrafish embryo development: Implications for reproductive health
Noise pollution has become a significant concern for human health, yet its effects on early embryonic development remain underexplored. Specifically, data on the impact of sine wave noise on newly fertilized embryos is limited. This study aimed to address this gap by using zebrafish embryos at the 1...
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| Format: | Article |
| Language: | English |
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Elsevier
2025-01-01
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| Series: | Ecotoxicology and Environmental Safety |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S0147651325000545 |
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| author | Yan Zuo Zhilan Bai Kaixuan Yang Ziyuan Lin Xiaolin Hu Huaqin Sun |
| author_facet | Yan Zuo Zhilan Bai Kaixuan Yang Ziyuan Lin Xiaolin Hu Huaqin Sun |
| author_sort | Yan Zuo |
| collection | DOAJ |
| description | Noise pollution has become a significant concern for human health, yet its effects on early embryonic development remain underexplored. Specifically, data on the impact of sine wave noise on newly fertilized embryos is limited. This study aimed to address this gap by using zebrafish embryos at the 1-cell stage as a model to assess the toxicity of sine waves, following OECD Test No. 236. We exposed embryos to sound levels of 90 decibels (dB) and above, observing increased deformity rates, delayed development, and reductions in body length, heart rate and brain size. To elucidate the molecular mechanisms underlying these effects, we employed transcriptomics, metabolomics, and epigenomics (m6A-MeRIP-seq). KEGG enrichment analysis revealed significant alterations in arachidonic acid metabolism, axon guidance, and ubiquitin-mediated proteolysis. In conclusion, our findings demonstrate that high levels of sine wave noise adversely affect early embryo development. These results provide crucial insights for developing strategies to mitigate noise pollution and protect early developmental stages. |
| format | Article |
| id | doaj-art-e3677aa6da6c4570bb0fa4429db8e5c0 |
| institution | Kabale University |
| issn | 0147-6513 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Ecotoxicology and Environmental Safety |
| spelling | doaj-art-e3677aa6da6c4570bb0fa4429db8e5c02025-01-23T05:26:13ZengElsevierEcotoxicology and Environmental Safety0147-65132025-01-01289117718Developmental and molecular effects of pure-tone sine wave exposure on early zebrafish embryo development: Implications for reproductive healthYan Zuo0Zhilan Bai1Kaixuan Yang2Ziyuan Lin3Xiaolin Hu4Huaqin Sun5Department of Gynecology and Obstetrics Nursing, West China Second University Hospital, Sichuan University/West China School of Nursing, Sichuan University, Sichuan, China; Key laboratory of Birth Defects and Related Disease of Women and Children (Sichuan University), Ministry of Education, Chengdu, Sichuan, ChinaDepartment of Gynecology and Obstetrics Nursing, West China Second University Hospital, Sichuan University/West China School of Nursing, Sichuan University, Sichuan, China; Key laboratory of Birth Defects and Related Disease of Women and Children (Sichuan University), Ministry of Education, Chengdu, Sichuan, ChinaDepartment of Gynecology and Obstetrics, West China Second University Hospital, Sichuan University/Key Laboratory of Birth Defects and Related Diseases of Women and Children (Sichuan University), Chengdu 610000, ChinaKey laboratory of Birth Defects and Related Disease of Women and Children (Sichuan University), Ministry of Education, Chengdu, Sichuan, China; SCU-CUHK Joint Laboratory for Reproductive Medicine, Zebrafish Research Platform, West China Second University Hospital, Children’s Medicine Key Laboratory of Sichuan Province, Sichuan University/Key Laboratory of Birth Defects and Related Diseases of Women and Children (Sichuan University), Ministry of Education, Chengdu 610000, PR ChinaWest China School of Nursing, Sichuan University/Department of Nursing, West China Hospital, Sichuan University, Chengdu 610000, ChinaKey laboratory of Birth Defects and Related Disease of Women and Children (Sichuan University), Ministry of Education, Chengdu, Sichuan, China; SCU-CUHK Joint Laboratory for Reproductive Medicine, Zebrafish Research Platform, West China Second University Hospital, Children’s Medicine Key Laboratory of Sichuan Province, Sichuan University/Key Laboratory of Birth Defects and Related Diseases of Women and Children (Sichuan University), Ministry of Education, Chengdu 610000, PR China; Correspondence author at: Key laboratory of Birth Defects and Related Disease of Women and Children (Sichuan University), Ministry of Education, Chengdu, Sichuan, China.Noise pollution has become a significant concern for human health, yet its effects on early embryonic development remain underexplored. Specifically, data on the impact of sine wave noise on newly fertilized embryos is limited. This study aimed to address this gap by using zebrafish embryos at the 1-cell stage as a model to assess the toxicity of sine waves, following OECD Test No. 236. We exposed embryos to sound levels of 90 decibels (dB) and above, observing increased deformity rates, delayed development, and reductions in body length, heart rate and brain size. To elucidate the molecular mechanisms underlying these effects, we employed transcriptomics, metabolomics, and epigenomics (m6A-MeRIP-seq). KEGG enrichment analysis revealed significant alterations in arachidonic acid metabolism, axon guidance, and ubiquitin-mediated proteolysis. In conclusion, our findings demonstrate that high levels of sine wave noise adversely affect early embryo development. These results provide crucial insights for developing strategies to mitigate noise pollution and protect early developmental stages.http://www.sciencedirect.com/science/article/pii/S0147651325000545NoiseSine waveZebrafishTranscriptomicsMetabolomics |
| spellingShingle | Yan Zuo Zhilan Bai Kaixuan Yang Ziyuan Lin Xiaolin Hu Huaqin Sun Developmental and molecular effects of pure-tone sine wave exposure on early zebrafish embryo development: Implications for reproductive health Ecotoxicology and Environmental Safety Noise Sine wave Zebrafish Transcriptomics Metabolomics |
| title | Developmental and molecular effects of pure-tone sine wave exposure on early zebrafish embryo development: Implications for reproductive health |
| title_full | Developmental and molecular effects of pure-tone sine wave exposure on early zebrafish embryo development: Implications for reproductive health |
| title_fullStr | Developmental and molecular effects of pure-tone sine wave exposure on early zebrafish embryo development: Implications for reproductive health |
| title_full_unstemmed | Developmental and molecular effects of pure-tone sine wave exposure on early zebrafish embryo development: Implications for reproductive health |
| title_short | Developmental and molecular effects of pure-tone sine wave exposure on early zebrafish embryo development: Implications for reproductive health |
| title_sort | developmental and molecular effects of pure tone sine wave exposure on early zebrafish embryo development implications for reproductive health |
| topic | Noise Sine wave Zebrafish Transcriptomics Metabolomics |
| url | http://www.sciencedirect.com/science/article/pii/S0147651325000545 |
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