Developmental and molecular effects of pure-tone sine wave exposure on early zebrafish embryo development: Implications for reproductive health

Noise pollution has become a significant concern for human health, yet its effects on early embryonic development remain underexplored. Specifically, data on the impact of sine wave noise on newly fertilized embryos is limited. This study aimed to address this gap by using zebrafish embryos at the 1...

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Main Authors: Yan Zuo, Zhilan Bai, Kaixuan Yang, Ziyuan Lin, Xiaolin Hu, Huaqin Sun
Format: Article
Language:English
Published: Elsevier 2025-01-01
Series:Ecotoxicology and Environmental Safety
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Online Access:http://www.sciencedirect.com/science/article/pii/S0147651325000545
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author Yan Zuo
Zhilan Bai
Kaixuan Yang
Ziyuan Lin
Xiaolin Hu
Huaqin Sun
author_facet Yan Zuo
Zhilan Bai
Kaixuan Yang
Ziyuan Lin
Xiaolin Hu
Huaqin Sun
author_sort Yan Zuo
collection DOAJ
description Noise pollution has become a significant concern for human health, yet its effects on early embryonic development remain underexplored. Specifically, data on the impact of sine wave noise on newly fertilized embryos is limited. This study aimed to address this gap by using zebrafish embryos at the 1-cell stage as a model to assess the toxicity of sine waves, following OECD Test No. 236. We exposed embryos to sound levels of 90 decibels (dB) and above, observing increased deformity rates, delayed development, and reductions in body length, heart rate and brain size. To elucidate the molecular mechanisms underlying these effects, we employed transcriptomics, metabolomics, and epigenomics (m6A-MeRIP-seq). KEGG enrichment analysis revealed significant alterations in arachidonic acid metabolism, axon guidance, and ubiquitin-mediated proteolysis. In conclusion, our findings demonstrate that high levels of sine wave noise adversely affect early embryo development. These results provide crucial insights for developing strategies to mitigate noise pollution and protect early developmental stages.
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institution Kabale University
issn 0147-6513
language English
publishDate 2025-01-01
publisher Elsevier
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series Ecotoxicology and Environmental Safety
spelling doaj-art-e3677aa6da6c4570bb0fa4429db8e5c02025-01-23T05:26:13ZengElsevierEcotoxicology and Environmental Safety0147-65132025-01-01289117718Developmental and molecular effects of pure-tone sine wave exposure on early zebrafish embryo development: Implications for reproductive healthYan Zuo0Zhilan Bai1Kaixuan Yang2Ziyuan Lin3Xiaolin Hu4Huaqin Sun5Department of Gynecology and Obstetrics Nursing, West China Second University Hospital, Sichuan University/West China School of Nursing, Sichuan University, Sichuan, China; Key laboratory of Birth Defects and Related Disease of Women and Children (Sichuan University), Ministry of Education, Chengdu, Sichuan, ChinaDepartment of Gynecology and Obstetrics Nursing, West China Second University Hospital, Sichuan University/West China School of Nursing, Sichuan University, Sichuan, China; Key laboratory of Birth Defects and Related Disease of Women and Children (Sichuan University), Ministry of Education, Chengdu, Sichuan, ChinaDepartment of Gynecology and Obstetrics, West China Second University Hospital, Sichuan University/Key Laboratory of Birth Defects and Related Diseases of Women and Children (Sichuan University), Chengdu 610000, ChinaKey laboratory of Birth Defects and Related Disease of Women and Children (Sichuan University), Ministry of Education, Chengdu, Sichuan, China; SCU-CUHK Joint Laboratory for Reproductive Medicine, Zebrafish Research Platform, West China Second University Hospital, Children’s Medicine Key Laboratory of Sichuan Province, Sichuan University/Key Laboratory of Birth Defects and Related Diseases of Women and Children (Sichuan University), Ministry of Education, Chengdu 610000, PR ChinaWest China School of Nursing, Sichuan University/Department of Nursing, West China Hospital, Sichuan University, Chengdu 610000, ChinaKey laboratory of Birth Defects and Related Disease of Women and Children (Sichuan University), Ministry of Education, Chengdu, Sichuan, China; SCU-CUHK Joint Laboratory for Reproductive Medicine, Zebrafish Research Platform, West China Second University Hospital, Children’s Medicine Key Laboratory of Sichuan Province, Sichuan University/Key Laboratory of Birth Defects and Related Diseases of Women and Children (Sichuan University), Ministry of Education, Chengdu 610000, PR China; Correspondence author at: Key laboratory of Birth Defects and Related Disease of Women and Children (Sichuan University), Ministry of Education, Chengdu, Sichuan, China.Noise pollution has become a significant concern for human health, yet its effects on early embryonic development remain underexplored. Specifically, data on the impact of sine wave noise on newly fertilized embryos is limited. This study aimed to address this gap by using zebrafish embryos at the 1-cell stage as a model to assess the toxicity of sine waves, following OECD Test No. 236. We exposed embryos to sound levels of 90 decibels (dB) and above, observing increased deformity rates, delayed development, and reductions in body length, heart rate and brain size. To elucidate the molecular mechanisms underlying these effects, we employed transcriptomics, metabolomics, and epigenomics (m6A-MeRIP-seq). KEGG enrichment analysis revealed significant alterations in arachidonic acid metabolism, axon guidance, and ubiquitin-mediated proteolysis. In conclusion, our findings demonstrate that high levels of sine wave noise adversely affect early embryo development. These results provide crucial insights for developing strategies to mitigate noise pollution and protect early developmental stages.http://www.sciencedirect.com/science/article/pii/S0147651325000545NoiseSine waveZebrafishTranscriptomicsMetabolomics
spellingShingle Yan Zuo
Zhilan Bai
Kaixuan Yang
Ziyuan Lin
Xiaolin Hu
Huaqin Sun
Developmental and molecular effects of pure-tone sine wave exposure on early zebrafish embryo development: Implications for reproductive health
Ecotoxicology and Environmental Safety
Noise
Sine wave
Zebrafish
Transcriptomics
Metabolomics
title Developmental and molecular effects of pure-tone sine wave exposure on early zebrafish embryo development: Implications for reproductive health
title_full Developmental and molecular effects of pure-tone sine wave exposure on early zebrafish embryo development: Implications for reproductive health
title_fullStr Developmental and molecular effects of pure-tone sine wave exposure on early zebrafish embryo development: Implications for reproductive health
title_full_unstemmed Developmental and molecular effects of pure-tone sine wave exposure on early zebrafish embryo development: Implications for reproductive health
title_short Developmental and molecular effects of pure-tone sine wave exposure on early zebrafish embryo development: Implications for reproductive health
title_sort developmental and molecular effects of pure tone sine wave exposure on early zebrafish embryo development implications for reproductive health
topic Noise
Sine wave
Zebrafish
Transcriptomics
Metabolomics
url http://www.sciencedirect.com/science/article/pii/S0147651325000545
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