Whole‐genome sequencing of cell‐free DNA reveals DNA of tumor origin in plasma from patients with colorectal adenomas

Whole‐genome sequencing of cell‐free DNA reveals DNA of tumor origin in plasma from patients with colorectal adenomas

The presence of circulating tumor DNA (ctDNA) in patients with colorectal adenomas remains uncertain. Studies using tumor‐agnostic approaches report ctDNA in 10–15% of patients, though with uncertainty as to whether the signal originates from the adenoma. To obtain an accurate estimate of the propor...

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Main Authors: Amanda Frydendahl, Adam J. Widman, Nadia Øgaard, Anushri Arora, Daniel Halmos, Jesper Nors, Johanne Ahrenfeldt, Tenna V. Henriksen, Christina Demuth, Line Raaby, Mads H. Rasmussen, Christina Therkildsen, Dan A. Landau, Claus L. Andersen
Format: Article
Language:English
Published: Wiley 2025-04-01
Series:Molecular Oncology
Subjects:
adenomas
circulating tumor DNA
colorectal cancer
early detection
whole‐genome sequencing
Online Access:https://doi.org/10.1002/1878-0261.13803
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https://doi.org/10.1002/1878-0261.13803

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