Computational and biological modeling of IGF1R inhibition for multifocal medulloblastoma

Computational and biological modeling of IGF1R inhibition for multifocal medulloblastoma

Abstract Background Leptomeningeal metastasis in medulloblastoma poses challenges for effective treatments due to the blood–brain barrier (BBB), which may be addressed through intrathecal or intraventricular drug delivery. However, the lack of pharmacokinetic modeling for pathological cerebrospinal...

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Main Authors: Alyssa G. Almer, Samuel V. Rasmussen, Dina Kats, Matthew N. Svalina, Bonnie L. Cole, Mohammadreza Khani, Sonja Chen, Samuel H. Cheshier, Bryn A. Martin, Noah E. Berlow, Charles Keller
Format: Article
Language:English
Published: Nature Portfolio 2025-05-01
Series:Communications Medicine
Online Access:https://doi.org/10.1038/s43856-025-00925-4
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https://doi.org/10.1038/s43856-025-00925-4

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