Metformin reverts aortic calcifications and elastin loss induced by an experimental metabolic syndrome

Metformin reverts aortic calcifications and elastin loss induced by an experimental metabolic syndrome

Metabolic syndrome (MetS) is associated with osteogenic transdifferentiation of vascular smooth muscle cells (VSMCs) and accumulation of arterial calcifications (ACs). Metformin (MET) inhibits this transdifferentiation in vitro. Here, we evaluate the in vivo efficacy of oral MET to reduce AC in a mo...

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Bibliographic Details
Main Authors: Lucas Streckwall, Nancy Martini, Claudia Sedlinsky, León Schurman, María Virginia Gangoiti, Antonio Desmond McCarthy
Format: Article
Language:English
Published: Bioscientifica 2025-01-01
Series:Endocrine Connections
Subjects:
fructose
metabolic syndrome
metformin
vascular smooth muscle cells
osteogenic transdifferentiation
advanced glycation end-products
receptor for advanced glycation end-products
Online Access:https://ec.bioscientifica.com/view/journals/ec/14/2/EC-24-0714.xml
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