One pot synthesis of a novel bioactive compound employing a deep eutectic solvent grafted MWCNT system in a solventless environment
Abstract Heterogeneous catalysis is considered as a suitable alternative to conventional organic synthesis for the selective production of industrially significant fine chemicals. The development of supported catalysts by dispersing minimal quantities of active component can reduce production costs...
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Nature Portfolio
2025-07-01
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| Online Access: | https://doi.org/10.1038/s41598-025-11153-0 |
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| author | Laveena Mariet Veigas Lokesh Ravi G. Santhosh Lokesh S. Kumar P. Nikhil Chandra Mothi Krishna Mohan |
| author_facet | Laveena Mariet Veigas Lokesh Ravi G. Santhosh Lokesh S. Kumar P. Nikhil Chandra Mothi Krishna Mohan |
| author_sort | Laveena Mariet Veigas |
| collection | DOAJ |
| description | Abstract Heterogeneous catalysis is considered as a suitable alternative to conventional organic synthesis for the selective production of industrially significant fine chemicals. The development of supported catalysts by dispersing minimal quantities of active component can reduce production costs and enhance energy efficiency. The current work reports the development of Deep eutectic solvent (DES) modified multiwalled carbon nanotube (MWCNT) system and its activity in the Knoevenagel condensation reaction. The catalytic system was developed by grinding a very low concentration (0.83mM) of DES with desired amount of MWCNT. Various interactions of the three component DES with MWCNT were analysed by X-ray photoelectron spectroscopy (XPS). The reaction favoured a novel compound selectively with yield around 92% in solvent free medium. Anti-cancerous studies of the synthesized compound demonstrated a strong IC50 value of 15.62 µg/ml and a statistically calculated IC50 value of 9.8 µg/ml. Acridine orange/ Ethidium Bromide (AO/EB) dual fluorescence staining studies revealed that the test ligand with lowest concentration of 7.8 µg/ml was capable to induce apoptosis in 100% of MCF-7 cells. It is evident from the studies that the synthesized compound is a strong anticancer agent with potential to be investigated further. |
| format | Article |
| id | doaj-art-e2fad0338a7f4e699f0c809c15ae3bcb |
| institution | Kabale University |
| issn | 2045-2322 |
| language | English |
| publishDate | 2025-07-01 |
| publisher | Nature Portfolio |
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| series | Scientific Reports |
| spelling | doaj-art-e2fad0338a7f4e699f0c809c15ae3bcb2025-08-20T03:42:25ZengNature PortfolioScientific Reports2045-23222025-07-0115111510.1038/s41598-025-11153-0One pot synthesis of a novel bioactive compound employing a deep eutectic solvent grafted MWCNT system in a solventless environmentLaveena Mariet Veigas0Lokesh Ravi1G. Santhosh2Lokesh S. Kumar3P. Nikhil Chandra4Mothi Krishna Mohan5Department of Sciences and Humanities, School of Engineering and Technology, Christ UniversityDepartment of Biomedical Sciences, School of Health Sciences, The Apollo UniversityDepartment of Sciences and Humanities, School of Engineering and Technology, Christ UniversityDepartment of Sciences and Humanities, School of Engineering and Technology, Christ UniversityP.G. and Research Department of Chemistry, Sree Narayana CollegeDepartment of Sciences and Humanities, School of Engineering and Technology, Christ UniversityAbstract Heterogeneous catalysis is considered as a suitable alternative to conventional organic synthesis for the selective production of industrially significant fine chemicals. The development of supported catalysts by dispersing minimal quantities of active component can reduce production costs and enhance energy efficiency. The current work reports the development of Deep eutectic solvent (DES) modified multiwalled carbon nanotube (MWCNT) system and its activity in the Knoevenagel condensation reaction. The catalytic system was developed by grinding a very low concentration (0.83mM) of DES with desired amount of MWCNT. Various interactions of the three component DES with MWCNT were analysed by X-ray photoelectron spectroscopy (XPS). The reaction favoured a novel compound selectively with yield around 92% in solvent free medium. Anti-cancerous studies of the synthesized compound demonstrated a strong IC50 value of 15.62 µg/ml and a statistically calculated IC50 value of 9.8 µg/ml. Acridine orange/ Ethidium Bromide (AO/EB) dual fluorescence staining studies revealed that the test ligand with lowest concentration of 7.8 µg/ml was capable to induce apoptosis in 100% of MCF-7 cells. It is evident from the studies that the synthesized compound is a strong anticancer agent with potential to be investigated further.https://doi.org/10.1038/s41598-025-11153-0MWCNTDeep eutectic solventGraftingKnoevenagel condensationCytotoxicity |
| spellingShingle | Laveena Mariet Veigas Lokesh Ravi G. Santhosh Lokesh S. Kumar P. Nikhil Chandra Mothi Krishna Mohan One pot synthesis of a novel bioactive compound employing a deep eutectic solvent grafted MWCNT system in a solventless environment Scientific Reports MWCNT Deep eutectic solvent Grafting Knoevenagel condensation Cytotoxicity |
| title | One pot synthesis of a novel bioactive compound employing a deep eutectic solvent grafted MWCNT system in a solventless environment |
| title_full | One pot synthesis of a novel bioactive compound employing a deep eutectic solvent grafted MWCNT system in a solventless environment |
| title_fullStr | One pot synthesis of a novel bioactive compound employing a deep eutectic solvent grafted MWCNT system in a solventless environment |
| title_full_unstemmed | One pot synthesis of a novel bioactive compound employing a deep eutectic solvent grafted MWCNT system in a solventless environment |
| title_short | One pot synthesis of a novel bioactive compound employing a deep eutectic solvent grafted MWCNT system in a solventless environment |
| title_sort | one pot synthesis of a novel bioactive compound employing a deep eutectic solvent grafted mwcnt system in a solventless environment |
| topic | MWCNT Deep eutectic solvent Grafting Knoevenagel condensation Cytotoxicity |
| url | https://doi.org/10.1038/s41598-025-11153-0 |
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