The MEC-2E isoform with a large C-terminal completely rescues the touch sensation defect of C. elegans

The MEC-2E isoform with a large C-terminal completely rescues the touch sensation defect of C. elegans

Abstract Human podocin and C. elegans MEC-2 belong to the stomatin protein superfamily. They share 49% identity and 91% similarity both in the evolutionary conserved PHB domain (123-284 aa) and in the oligomerization region (273-351 aa). Amino acid substitutions in these conserved regions can modify...

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Main Authors: Tália Magdolna Keszthelyi, Regina Légrádi, Dóra Pálya, Tímea Köles, Ágnes Regős, Dóra Karancsiné Menyhárd, Kálmán Tory
Format: Article
Language:English
Published: Nature Portfolio 2025-07-01
Series:Scientific Reports
Subjects:
Functional transcript
Mechanosensation
Chemotaxis
Mec-2
Online Access:https://doi.org/10.1038/s41598-025-10711-w
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https://doi.org/10.1038/s41598-025-10711-w

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