Microbial Composition, Disease Trajectory and Genetic Background in a Slow Onset Model of Frontotemporal Lobar Degeneration

Microbial Composition, Disease Trajectory and Genetic Background in a Slow Onset Model of Frontotemporal Lobar Degeneration

Slow-onset neurodegenerative disease in a low-expresser 2N4R P301L transgenic (Tg) mouse model is marked by neuroinflammation and by differing patterns of CNS deposition and accumulation of tau conformers, with such heterogeneities present even within inbred backgrounds. Gut microbial genotypes were...

Full description

Saved in:
Bibliographic Details
Main Authors: Nathalie Daude, Ivana Machado, Luis Arce, Jing Yang, David Westaway
Format: Article
Language:English
Published: MDPI AG 2025-04-01
Series:Biomolecules
Subjects:
tauopathy
protein misfolding
microbiome
transgenic mouse
frontotemporal dementia
neurodegeneration
Online Access:https://www.mdpi.com/2218-273X/15/5/636
Tags: Add Tag
No Tags, Be the first to tag this record!

Internet

https://www.mdpi.com/2218-273X/15/5/636

Similar Items