Structural basis for saxitoxin congener binding and neutralization by anuran saxiphilins

Structural basis for saxitoxin congener binding and neutralization by anuran saxiphilins

Abstract Dinoflagellates and cyanobacteria produce saxitoxin (STX) and ~50 congeners that disrupt bioelectrical signals by blocking voltage-gated sodium channels (NaVs). Consuming seafood carrying these toxins causes paralytic shellfish poisoning (PSP). Although NaVs and anuran STX binding proteins...

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Main Authors: Sandra Zakrzewska, Samantha A. Nixon, Zhou Chen, Holly S. Hajare, Elizabeth R. Park, John V. Mulcahy, Kandis M. Arlinghaus, Eduard Neu, Kirill Konovalov, Davide Provasi, Tod A. Leighfield, Marta Filizola, J. Du Bois, Daniel L. Minor
Format: Article
Language:English
Published: Nature Portfolio 2025-04-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-025-58903-2
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https://doi.org/10.1038/s41467-025-58903-2

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