An evolutionarily conserved metabolite inhibits biofilm formation in Escherichia coli K-12

An evolutionarily conserved metabolite inhibits biofilm formation in Escherichia coli K-12

Abstract Methylerythritol cyclodiphosphate (MEcPP) is an intermediate in the biosynthesis of isoprenoids in plant plastids and in bacteria, and acts as a stress signal in plants. Here, we show that MEcPP regulates biofilm formation in Escherichia coli K-12 MG1655. Increased MEcPP levels, triggered b...

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Main Authors: Jingzhe Guo, Wilhelmina T Van De Ven, Aleksandra Skirycz, Venkatesh P. Thirumalaikumar, Liping Zeng, Quanqing Zhang, Gerd Ulrich Balcke, Alain Tissier, Katayoon Dehesh
Format: Article
Language:English
Published: Nature Portfolio 2024-11-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-024-54501-w
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https://doi.org/10.1038/s41467-024-54501-w

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