Development of a novel adenovirus type 4 vector as a promising respiratory vaccine vehicle

Development of a novel adenovirus type 4 vector as a promising respiratory vaccine vehicle

IntroductionAdenovirus (Ad) vectors are widely used for gene delivery, and some of them have been approved for vaccine development. In particular, the recombinant COVID-19 vaccine for inhalation, which was developed using adenovirus type 5 (Ad5), represents a milestone in respiratory immunization. O...

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Bibliographic Details
Main Authors: Jinghan Xu, Busen Wang, Zhenghao Zhao, Shipo Wu, Zhe Zhang, Shuling Liu, Nan Huo, Wanru Zheng, Yi Chen, Zhiqiang Gao, Zuyuan Jia, Tianyu Liu, Li Zhu, Lihua Hou
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-04-01
Series:Frontiers in Immunology
Subjects:
adenovirus
viral vector
vaccine
mucosal immunity
immune response
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2025.1572081/full
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https://www.frontiersin.org/articles/10.3389/fimmu.2025.1572081/full

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