Sex differences in metabolic regulation by Gi/o-coupled receptor modulation of exocytosis

Sex differences in metabolic regulation by Gi/o-coupled receptor modulation of exocytosis

BackgroundPresynaptic Gi/o coupled GPCRs can act as negative feedback regulators of neurotransmitter release via Gβγ effector modulation through two mechanisms: decreased calcium influx and direct inhibition of membrane fusion by soluble N-ethylmaleimide—sensitive factor attachment protein (SNAP) re...

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Bibliographic Details
Main Authors: Montana Young, Ryan P. Ceddia, Analisa Thompson-Gray, David Reyes, Jackson B. Cassada, Julio E. Ayala, Owen P. McGuinness, Sheila Collins, Heidi E. Hamm
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-03-01
Series:Frontiers in Pharmacology
Subjects:
g protein coupled receptor (GPCR)
sex hormone
metabolism
norepinephrene
diet induced obesity (DIO)
exocytosis
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2025.1544456/full
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https://www.frontiersin.org/articles/10.3389/fphar.2025.1544456/full

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