Tebentafusp, a T cell engager, promotes macrophage reprogramming and in combination with IL-2 overcomes macrophage immunosuppression in cancer

Tebentafusp, a T cell engager, promotes macrophage reprogramming and in combination with IL-2 overcomes macrophage immunosuppression in cancer

Abstract Uveal melanoma (UM) is the most common intraocular cancer in adults, with metastatic disease (mUM) occurring in approximately half of the patients. Tebentafusp, an immune-mobilizing monoclonal T cell receptor against cancer (ImmTAC), is a therapeutic shown to improve overall survival (OS) i...

Full description

Saved in:
Bibliographic Details
Main Authors: Esra Güç, Agatha Treveil, Emma Leach, Anna Broomfield, Antonio Camera, James Clubley, Paula Nieto Garcia, Anastasiya Kazachenka, Rahul Khanolkar, Luis del Carpio, Holger Heyn, Jessica C. Hassel, Joseph J. Sacco, Sarah Stanhope, Laura Collins, Josep M. Piulats, Koustubh Ranade, Adel Benlahrech
Format: Article
Language:English
Published: Nature Portfolio 2025-03-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-025-57470-w
Tags: Add Tag
No Tags, Be the first to tag this record!

Internet

https://doi.org/10.1038/s41467-025-57470-w

Similar Items