Rapid Detection of <i>PML::RARA</i> Fusions in Acute Promyelocytic Leukemia: CRISPR/Cas9 Nanopore Sequencing with Adaptive Sampling

Rapid Detection of <i>PML::RARA</i> Fusions in Acute Promyelocytic Leukemia: CRISPR/Cas9 Nanopore Sequencing with Adaptive Sampling

Acute promyelocytic leukemia (APL) accounts for approximately 10–15% of newly diagnosed acute myeloid leukemia cases and presents with coagulopathy and bleeding. Prompt diagnosis and treatment are required to minimize early mortality in APL as initiation of all-trans retinoic acid therapy rapidly re...

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Main Authors: William Middlezong, Victoria Stinnett, Michael Phan, Brian Phan, Laura Morsberger, Melanie Klausner, Jen Ghabrial, Natalie DeMetrick, Jing Zhu, Trisha James, Aparna Pallavajjala, Christopher D. Gocke, Maria R. Baer, Ying S. Zou
Format: Article
Language:English
Published: MDPI AG 2024-12-01
Series:Biomolecules
Subjects:
CRISPR/Cas9
nanopore sequencing
<i>PML::RARA</i> fusions
acute promyelocytic leukemia
adaptive sampling
Online Access:https://www.mdpi.com/2218-273X/14/12/1595
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