Brain cross‐protection against SARS‐CoV‐2 variants by a lentiviral vaccine in new transgenic mice

Brain cross‐protection against SARS‐CoV‐2 variants by a lentiviral vaccine in new transgenic mice

Abstract COVID‐19 vaccines already in use or in clinical development may have reduced efficacy against emerging SARS‐CoV‐2 variants. In addition, although the neurotropism of SARS‐CoV‐2 is well established, the vaccine strategies currently developed have not taken into account protection of the cent...

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Main Authors: Min‐Wen Ku, Pierre Authié, Maryline Bourgine, François Anna, Amandine Noirat, Fanny Moncoq, Benjamin Vesin, Fabien Nevo, Jodie Lopez, Philippe Souque, Catherine Blanc, Ingrid Fert, Sébastien Chardenoux, llta Lafosse, Delphine Cussigh, David Hardy, Kirill Nemirov, Françoise Guinet, Francina Langa Vives, Laleh Majlessi, Pierre Charneau
Format: Article
Language:English
Published: Springer Nature 2021-10-01
Series:EMBO Molecular Medicine
Subjects:
central nervous system
hACE2 transgenic mice
intranasal vaccination
olfactory bulb
SARS‐CoV‐2 emerging variants of concern
Online Access:https://doi.org/10.15252/emmm.202114459
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https://doi.org/10.15252/emmm.202114459

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