The fungal expel of 5-fluorocytosine derived fluoropyrimidines mitigates its antifungal activity and generates a cytotoxic environment.

Invasive aspergillosis remains one of the most devastating fungal diseases and is predominantly linked to infections caused by the opportunistic human mold pathogen Aspergillus fumigatus. Major treatment regimens for the disease comprise the administration of antifungals belonging to the azole, poly...

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Bibliographic Details
Main Authors: Luis Enrique Sastré-Velásquez, Alex Dallemulle, Alexander Kühbacher, Clara Baldin, Laura Alcazar-Fuoli, Anna Niedrig, Christoph Müller, Fabio Gsaller
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2022-12-01
Series:PLoS Pathogens
Online Access:https://journals.plos.org/plospathogens/article/file?id=10.1371/journal.ppat.1011066&type=printable
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