Effect of fluid flow-induced shear stress on the behavior of synovial fibroblasts in a bioinspired synovium-on-chip model

Effect of fluid flow-induced shear stress on the behavior of synovial fibroblasts in a bioinspired synovium-on-chip model

ABSTRACT: Introduction: Due to the loading of the articular joints and the movement of the joint itself, mechanical stress is constantly exerted on the synovial cavity, which is, in turn, reflected as shear stress toward the surrounding tissues, including the synovium. Although it is known that syn...

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Bibliographic Details
Main Authors: Susanna Piluso, Yang Li, Liliana Moreira Texeira, Prasanna Padmanaban, Jeroen Rouwkema, Jeroen Leijten, René van Weeren, Marcel Karperien, Jos Malda
Format: Article
Language:English
Published: Elsevier 2025-06-01
Series:Journal of Cartilage & Joint Preservation
Subjects:
Articular joints
In vitro models
Inflammation
Microphysiological systems
Organ-on-chip
Osteoarthritis
Online Access:http://www.sciencedirect.com/science/article/pii/S2667254525000010
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