Inhibition of Putative Ibrutinib Targets Promotes Atrial Fibrillation, Conduction Blocks, and Proarrhythmic Electrocardiogram Indices: A Mendelian Randomization Analysis

Inhibition of Putative Ibrutinib Targets Promotes Atrial Fibrillation, Conduction Blocks, and Proarrhythmic Electrocardiogram Indices: A Mendelian Randomization Analysis

ABSTRACT Background The mechanism by which ibrutinib, a Bruton's tyrosine kinase inhibitor, can elevate the risk of arrhythmias is not fully elucidated. In this study, we explored how inhibition of off‐target kinases can contribute to this phenomenon. Methods We performed a Mendelian randomizat...

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Bibliographic Details
Main Authors: Hongxuan Xu, Bingxun Li, Pinchao Lv, Ying Chen, Yanyun Lin, An Zhang, Jing Zhao, Guoxiong Zhou, Lin Wu
Format: Article
Language:English
Published: Wiley 2025-04-01
Series:Cancer Innovation
Subjects:
atrial fibrillation
blood pressure
heart rate variability
P wave terminal force
QRS duration
QTc interval
Online Access:https://doi.org/10.1002/cai2.70004
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https://doi.org/10.1002/cai2.70004

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