Ophiopogonin D improves pancreatic islet cell dedifferentiation to treat diabetes by regulating the GRP78/ROS/PDX1 signaling pathway

Ophiopogonin D improves pancreatic islet cell dedifferentiation to treat diabetes by regulating the GRP78/ROS/PDX1 signaling pathway

IntroductionThe incidence of diabetes is rising annually, significantly impacting public health and imposing a substantial economic burden on society. Ophiopogonin D (Op D) exhibits certain hypoglycemic effects; however, its mechanisms remain unclear.Methodsβ-cell dedifferentiation, distinct from β-...

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Main Authors: Haoxiang Sun, Ruixiang Tan, Yongzhi Sun, Yimeng Li, Ying Xie, Cheng Zhang, Jianping Song, Wei Zhu, Jiuyao Zhou, Changsheng Deng, Manxue Mei
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-04-01
Series:Frontiers in Pharmacology
Subjects:
ophiopogonin D
dedifferentiation
diabetes
GRP78/ROS/PDX1
unfolded protein response
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2025.1563201/full
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https://www.frontiersin.org/articles/10.3389/fphar.2025.1563201/full

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