Fenvalerate exposure induces AKT/AMPK-dependent alterations in glucose metabolism in hepatoma cells

BackgroundFenvalerate (Fen) is a synthetic pyrethroid insecticide significantly associated with an increased risk of type 2 diabetes. Tumor cells exhibit a shift in glucose metabolism, known as the Warburg effect. Accordingly, we aimed to elucidate whether Fen interferes with insulin signaling and a...

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Bibliographic Details
Main Authors: Lu Sun, Zheng-Guo Cui, Qianwen Feng, Jibran Sualeh Muhammad, Yu-Jie Jin, Songji Zhao, Lingqi Zhou, Cheng-AI Wu
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-02-01
Series:Frontiers in Pharmacology
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Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2025.1540567/full
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