H5N1 avian influenza virus PB2 antagonizes duck IFN-β signaling pathway by targeting mitochondrial antiviral signaling protein

H5N1 avian influenza virus PB2 antagonizes duck IFN-β signaling pathway by targeting mitochondrial antiviral signaling protein

Type I interferon (IFN)-mediated innate immune responses represent the first line of host defense against viral infection. However, the molecular mechanisms by which avian influenza virus (AIV) inhibits type I IFN production in ducks are not well understood. Here, we first found that the polymerase...

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Bibliographic Details
Main Authors: Zuxian Chen, Bingbing Zhao, Yingying Wang, Yuqing Du, Siyu Feng, Junsheng Zhang, Luxiang Zhao, Weiqiang Li, Yangbao Ding, Peirong Jiao
Format: Article
Language:English
Published: KeAi Communications Co., Ltd. 2025-09-01
Series:Journal of Integrative Agriculture
Subjects:
avian influenza virus
polymerase basic 2
mitochondrial antiviral signaling protein
duck
type I interferon
Online Access:http://www.sciencedirect.com/science/article/pii/S2095311923004872
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