Challenges in Amplicon-Based DNA NGS Identification of MET Exon 14 Skipping Events in Non-Small Cell Lung Cancers

Challenges in Amplicon-Based DNA NGS Identification of MET Exon 14 Skipping Events in Non-Small Cell Lung Cancers

<b>Introduction:</b> <i>MET</i> Exon 14 skipping alterations are drivers of non-small cell lung carcinoma (NSCLC) with responses to tyrosine kinase inhibitors. Amplicon-based DNA NGS assays (DNA NGSs) for the detection of <i>MET</i>ex14 skipping can yield false-ne...

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Main Authors: Magdalena Jurkiewicz, Raymond Yeh, Catherine A. Shu, Susan J. Hsiao, Mahesh M. Mansukhani, Anjali Saqi, Helen Fernandes
Format: Article
Language:English
Published: MDPI AG 2025-02-01
Series:Journal of Molecular Pathology
Subjects:
<i>MET</i> exon 14 skipping
DNA NGS
RNA sequencing
lung adenocarcinoma
Online Access:https://www.mdpi.com/2673-5261/6/1/5
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