Exosomes containing long non-coding RNA AGAP2-AS1 promote the differentiation of CD4+ T cells through the miR-424-5p/SGK1 axis in psoriasis

Exosomes containing long non-coding RNA AGAP2-AS1 promote the differentiation of CD4+ T cells through the miR-424-5p/SGK1 axis in psoriasis

BackgroundLong non-coding RNAs (lncRNAs) have been implicated in the pathogenesis of autoimmune diseases. Our previous research demonstrated that AGAP2-AS1 in keratinocytes is involved in the pathogenesis of psoriasis, but its effect on CD4+ T cell differentiation remains unclear.MethodsExosomes wer...

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Bibliographic Details
Main Authors: Ziqi Yuan, Xue Zeng, Xiwei Zhang, Chenglai Xia, Xuebiao Peng
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-05-01
Series:Frontiers in Genetics
Subjects:
long non-coding RNAs
micrornas
psoriasis
t cells
exosomes
Online Access:https://www.frontiersin.org/articles/10.3389/fgene.2025.1521470/full
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